ARRS Case of the Week
NUCLEAR MEDICINE: Musculoskeletal
Case Author: Gary A. Ulaner, MD, PhD, Memorial Sloan-Kettering Cancer Center
58-year-old woman with bilateral leg pain and stiffness.
Posterior (left) and anterior (right) planar bone scans show bilateral diffuse periosteal uptake in the lower extremities.
- Hypertrophic osteoarthropathy
- Insufficiency fractures
- Shin splints
Hypertrophic osteoarthropathy (HOA) is a syndrome of long bone periostitis, digit clubbing, and bone and joint pain. HOA can be primary (without underlying cause) or secondary. Secondary HOA can be caused by pulmonary, pleural, cardiac, or abdominal disease, including lung cancer, tuberculosis, fibrous tumor of the pleura, ulcerative colitis, Crohn disease, and gastrointestinal neoplasms. In patients with symptoms of shin splints and normal radiographic findings, both bone scan and MRI may depict abnormalities occult on radiographs. Bone scintigraphy and MRI are more sensitive than radiography for detection of pelvic insufficiency fractures.
Davies RA, Darby M, Richards MA. Hypertrophic pulmonary osteoarthropathy in pulmonary metastatic disease: a case report and review of the literature. Clin Radiol
Martinez-Lavin M, Vargas A, Rivera-Viñas M. Hypertrophic osteoarthropathy: a palindrome with a pathogenic connotation. Curr Opin Rheumatol
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